Xenobiotic toxicity prediction combined with xenobiotic metabolism prediction in the human body
نویسندگان
چکیده
منابع مشابه
Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans.
Human CYP3A is the most abundant P450 isozyme present in the human liver and small intestine, and metabolizes around 50% of medical drugs on the market. The human CYP3A subfamily comprises four members (CYP3A4, CYP3A5, CYP3A7, CYP3A43) encoded on human chromosome 7. However, transgenic mouse lines carrying the entire human CYP3A cluster have not been constructed because of limitations in conven...
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The steroid and xenobiotic receptor (SXR) (also known as pregnane X receptor or PXR) is a nuclear hormone receptor activated by a diverse array of endogenous hormones, dietary steroids, pharmaceutical agents, and xenobiotic compounds. SXR has an enlarged, flexible, hydrophobic ligand binding domain (LBD) which is remarkably divergent across mammalian species and SXR exhibits considerable differ...
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We present a new symbolic computational approach to elucidate the biochemical networks of living systems de novo and we apply it to an important biomedical problem: xenobiotic metabolism. A crucial issue in analyzing and modeling a living organism is understanding its biochemical network beyond what is already known. Our objective is to use the available metabolic information in a representatio...
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ژورنال
عنوان ژورنال: Biomeditsinskaya Khimiya
سال: 2019
ISSN: 2310-6905,2310-6972
DOI: 10.18097/pbmc20196502114